Melatonin, an important anti-aging health supplement
Among the various hormonal supplements that have become popular over the
last few years, melatonin has been the first, propelled by the book on the
Melatonin Miracle by the Italian researcher Walter Pierpaoli.
Melatonin is a hormone secreted by the pineal gland, and among other
things, it is largely responsible for regulating wake / sleep cycles.
Melatonin supplements will often improve sleep in patients who have a hard
time falling asleep or sleeping for a sufficient number of hours.
However, melatonin became so popular not because of its effect on sleep but
because experiments with laboratory animals have shown that melatonin seems
to substantially increase life span.
Scientific research
on Melatonin
Neuroendocrine, immunohistochemical, and ultrastructural study of pineal region tumors. (Grimoldi N; J Pineal Res, 1998 Oct)
Pharmacological characterisation of melatonin mt1 receptor-mediated stimulation of [35S]-GTPgammaS binding. (Beresford IJ; Biochem Pharmacol, 1998 Nov 1)
Melatonin attenuates hydrogen peroxide toxicity in MCF7 cells only at pharmacological concentrations. (Baldwin WS; Biochem Biophys Res Commun, 1998 Sep 29)
Melatonin: the dark force. (Bergstrom WH; Adv Pediatr, 1998)
Twenty-four hour rhythm of melatonin in patients with a history of pineal and/or hypothalamo-neurohypophyseal germinoma. (Murata J; J Pineal Res, 1998 Oct)
Maternal-fetal transfer of melatonin in pregnant women near term. (Okatani Y; J Pineal Res, 1998 Oct)
Circadian secretion patterns of melatonin after major surgery. (Nishimura S; J Pineal Res, 1998 Sep)
Elevated nocturnal melatonin is a consequence of gonadotropin-releasing hormone deficiency in women with hypothalamic amenorrhea. (Kadva A; J Clin Endocrinol Metab, 1998 Oct)
Melatonin counteracts ischemia-induced apoptosis in human retinal pigment epithelial cells. (Osborne NN; Invest Ophthalmol Vis Sci, 1998 Nov)
Estrogen receptor transactivation in MCF-7 breast cancer cells by melatonin and growth factors. (Ram PT; Mol Cell Endocrinol, 1998 Jun 25)
Prospects of the clinical utilization of melatonin. (Bubenik GA; Biol Signals Recept, 1998 Jul-Aug)
Influence of melatonin on invasive and metastatic properties of MCF-7 human breast cancer cells. (Cos S; Cancer Res, 1998 Oct 1)
Melatonin regulates the respiratory burst of human neutrophils and their depolarization. (Pieri C; J Pineal Res, 1998 Jan)
Delayed sleep phase syndrome: A placebo-controlled cross-over study on the effects of melatonin administered five hours before the individual dim light melatonin onset. (Nagtegaal JE; J Sleep Res, 1998 Jun)
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